Hi. I'm having a grim time at present, as the increased risk of aggressive skin cancers triggered by the ruxolitinib I’m taking ( was inc to 20mg bd at end December to help the fatigue ( it didn’t) ( now back to 15mg bd) haunts me. I’ve already had one SCC excised from my face, as I’d posted, and a BCC taken off my back. I’d thought that reducing the rux and adding in Pegasys would make sense, My blood counts are stable: main issue was fatigue. ,
My haematologist doesn’t see it that way, despite the ongoing ruxopeg trials ( not at his hospital). His only offer so far is to be on the rux, or discontinue it .
Has anyone here with MF tried reducing rux and adding Peg? What was the dose/ sxgedule you used? Are there any haems on the UK who do this? If my haem had an apprpriate opinion he might be prepared to consider it
Prof Kiladjian in Paris ( who runs the ruxopeg trials) has no apts till 2020 - my sister lives in Patris and did some research for me.
Suggestions of UK haems to approach would be welcome .
Changing from rux to pegasys plus rux for mf
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Rachelthepotter
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Re: Changing from rux to pegasys plus rux for mf
Hey Rachel... 
I will try to alert Garry now... Sorry as I have only just returned home in our evening...
Hopefully, he shall respond back to you very soon...
Steve
I will try to alert Garry now... Sorry as I have only just returned home in our evening...
Hopefully, he shall respond back to you very soon...
Steve
Re: Changing from rux to pegasys plus rux for mf
Hi Rachel
I agree with you.... there are certainly some issues happening which obviously you will need to get on top of as quickly as possible. I'm not sure why your Haematologist doesn't want to compromise in this situation.
I am currently on Ruxolitinib 15 mg twice daily and 45 mcg once a week of pegylated Interferon. The only issue I have had with the combination is my hemoglobin has dropped. I haven't had any aggressive skin cancers on Ruxolitinib, but tell me were you taking HU before the Ruxolitinib.
To be honest if your Doctor is adamant he isn't interested in the combination, you will need to get another opinion... I think you mentioned Claire Harrison can you see what her thoughts are... or asked your GP to speak to her on your behalf.
At this stage the combination I am taking seems to be working and both my haematologist are hoping for a remission in the future.
Im happy to speak off line regarding this if it helps.
Regards
Garry
I agree with you.... there are certainly some issues happening which obviously you will need to get on top of as quickly as possible. I'm not sure why your Haematologist doesn't want to compromise in this situation.
I am currently on Ruxolitinib 15 mg twice daily and 45 mcg once a week of pegylated Interferon. The only issue I have had with the combination is my hemoglobin has dropped. I haven't had any aggressive skin cancers on Ruxolitinib, but tell me were you taking HU before the Ruxolitinib.
To be honest if your Doctor is adamant he isn't interested in the combination, you will need to get another opinion... I think you mentioned Claire Harrison can you see what her thoughts are... or asked your GP to speak to her on your behalf.
At this stage the combination I am taking seems to be working and both my haematologist are hoping for a remission in the future.
Im happy to speak off line regarding this if it helps.
Regards
Garry